Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
None of the patients analysed carried a NBS1 allele with the 657del5 mutation, suggesting that this mutation does not play a major role in the pathogenesis of NHL of childhood and adolescence.
|
10848790 |
2000 |
Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Although four variants, two in RAD50 and two in NBS1, showed association results suggestive of an effect on NHL, they were not significant after correction for multiple tests.
|
19917125 |
2009 |
Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The NBS1 mutation 657del5 on one allele was found in 3 of 270 patients with ALL and 2 of 212 children and adolescents with NHL; no carrier was found among 63 patients with Hodgkin lymphoma (HL).
|
16152606 |
2006 |
Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
These findings imply that heterozygous NBS1 germline mutations may contribute significantly to the overall incidence of NHL, especially of the gastrointestinal tract, in Central Europe.
|
16998789 |
2006 |
Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
LHGDN |
The NBS1 mutation 657del5 on one allele was found in 3 of 270 patients with ALL and 2 of 212 children and adolescents with NHL; no carrier was found among 63 patients with Hodgkin lymphoma (HL).
|
16152606 |
2006 |
Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In addition, our study provides suggestive evidence of an interaction between SNPs in MRE11A and NBS1 associated with NHL risk (OR = 0.51, 95% CI: 0.34-0.77, p = 0.0002).
|
25010664 |
2014 |
Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma.
|
17169801 |
2006 |
Lymphoma, Non-Hodgkin
|
0.370 |
CausalMutation
|
disease |
CGI |
|
|
|
Lymphoma, Non-Hodgkin
|
0.370 |
GeneticVariation
|
disease |
LHGDN |
These findings imply that heterozygous NBS1 germline mutations may contribute significantly to the overall incidence of NHL, especially of the gastrointestinal tract, in Central Europe.
|
16998789 |
2006 |
Lymphoma, Non-Hodgkin
|
0.370 |
PosttranslationalModification
|
disease |
BEFREE |
Mutations and molecular variants of the NBS1 gene in non-Hodgkin lymphoma.
|
12353271 |
2002 |